|
Project |
PI |
Partners |
Description |
Publications/Products |
|
Development of a Doubly Robust Estimation Tool to Estimate
Treatment Effects |
Jönsson-Funk |
SAS
Institute, Inc.; Duke CERTs |
Develop, test, validate, and disseminate a user-friendly
software tool for obtaining doubly robust estimates of treatment
effects in SAS®. Develop an accessible, user-friendly SAS tool
for Doubly Robust Estimation of large observational databases to
enable researchers to estimate treatment effects amidst
interaction and confounding in observational data |
Scheduled for presentation at the SAS Global Forum and release
on HarryGuess.unc.edu in April 2007 |
|
Risk
Communication Workshop |
Tolleson-Rinehart, Massie |
AAP |
Convene an expert group to begin distilling a systematic
review of the literature on off-label uses of ADHD drugs and
their consequences. Develop an educational tool on risk of
off-label drug use for physicians to give to parents. |
Workshop and tool dissemination scheduled for Summer 2007 |
|
Asthma Improvement for Rural Medicaid Patients |
Yeatts, Wegner |
NC
AccessCare, Inc. |
Improving capacity to provide highest quality asthma care in
remote areas Demonstration of strategies for facilitating rural
health care delivery |
On-going |
|
Impact of Antibiotic Resistance on the Management of Childhood
Infections: A community evidence-based approach |
Belhorn |
|
Clarify how and why antibiotic resistance differs in differing
populations, examining patterns and
prescribing practices and analyzing antibiotic efficacy, and
developing educational curricula to translate findings into
practice and policy.
Aiding
practitioners in understanding and preventing resistance.
|
On-going |
|
PEDS:
Pediatric Education for Drug Safety, a UNC CERTs Safety
Curriculum |
Tolleson-Rinehart |
Funded
by the Attorney General Consumer and Prescriber Education
Program |
Create an evidence-based, freely available continuing medical
education curriculum and conduct a randomized trial of its
effects on prescriber behavior. |
Expert Panel to convene in May 2007 |
|
Characteristics of End-of-Life Issues and Perceptions of Life
Care in Patients with Cystic Fibrosis |
Dellon |
|
Identify and overcome challenges in delivering high- quality
care at the end of life for cystic fibrosis patients. |
On-going. Poster presentation: Effects of Lung Transplantation
on Inpatient End of Life Care in Cystic Fibrosis. |
|
Smooth Transition to Adulthood with Renal Disease (STARx) |
Ferris |
Kate
B. Reynolds Charitable Trust |
Improving understanding of needs of patients with serious
condition during transition from pediatric to adult chronic care
Develop a tool to enable patients and their physicians to
determine the readiness of pediatric nephrology patients to move
to adult medical care |
On-going |
|
Rational Use of Oral Hypoglycemic Agents in Pediatric Type 2
Diabetes Mellitus |
Calikoglu |
|
Providing guidelines for providers faced with new therapeutic
needs |
On-going |
|
A
Validation Study of Neural Tube Defect Detection within the GPRD |
Andrews |
RTI
Health Solutions |
Use
the GPRD to determine whether certain asthma medications or
antiepileptic drugs pose a greater risk during pregnancy than
others and which educational tools best help to change
physicians' prescribing behavior |
On-going |
|
Quality and Safety Metrics in Pediatric Emergency Medicine
|
Hobgood |
|
Convene expert panels and using chart audit
templates to assess the evidence for quality metrics in
pediatric emergency medicine, with intermediate endorsement of
24 quality measures targeting the following conditions: asthma,
long bone fracture, closed head injury, diarrhea/dehydration,
croup, and urinary infection.
Development and
preliminary testing of two evidence based quality indicators for
pediatric emergency care. |
On-going |
|
Computerized Provider Order Entry and Medication Errors on the
Inpatient Service of a Children’s Hospital |
Stiles |
North
Carolina Children's Hospital |
Determine costs and benefits of health information and
computerized physician order entry (CPOE) to pediatric patient
safety.
|
On-going |
|
Harryguess.unc.edu |
UNC
CERTs Administrative Core |
|
Develop and maintain a website that serves as a valuable
resource on pharmacoepidemiology and pharmacovigilance.
HarryGuess.unc.edu is meant to be a locus for the free exchange
of tools and educational opportunities of all kinds. To begin
with, we are emphasizing pediatric therapeutics,
pharmacoepidemiology, and patient-reported outcomes, three of
Dr. Guess’s most important substantive research areas. We hope
to expand over time into other sources of higher quality and
more effective therapeutics use. |
Harry Guess Web Site |
|
Evaluation of Synagis Treatment for the Prevention of RSV
Infection in Children Using Medicaid Data |
Stiles |
NC
AccessCare, Inc. |
Develop cost effectiveness methodology for NC Medicaid that
includes relevant outcomes, costs; determine cost effectiveness
of Synagis with an EGA of 32-35 weeks who have no co-morbidity
and less than 2 risk factors; determine incidence of RSF and
cost effectiveness in subgroup of children with congenital heart
disease. Develop data for NC Medicaid children that will assist
in making decisions about the prophylactic use of Synagis.
|
Wegner Direct Cost Analyses of Palivizumab Treatment in a Cohort
of At-Risk Children: Evidence from the North Carolina Medicaid
Program. Wegner S, Jacobson Vann J, Liu G, Byrns P, Cypra C,
Campbell W, Stiles A. Pediatrics 2004; 114(6):1612-1619. |
|
Postmarketing Surveillance of Drugs in Emergency Department
Pediatric Patients |
Waller |
|
Contribute to national policymaking to standardize adverse drug
event reporting in emergency departments Establishing
feasibility of using ED databases to track adverse drug events.
|
Use
Of An Emergency Department Discharge Database For Drug-Induced
Anaphylaxis Surveillance Among Pediatric Patients. D'Aloisio AA,
Ringel-Kulka T, Waller AE, West SL, Bordley WC.
Pharmacoepidemiol Drug Safety 2005; 14(Suppl 2):S200. Abstract.
Manuscript submitted to the Journal of Pharmacoepidemiology &
Drug Safety |
|
Effect of AAP Guidelines on Vitamin D Supplementation
Recommendations in Practice |
Davenport |
|
National effort to improve recognition of vitamin D-deficient
rickets and promoting vitamin D supplementation among
pediatricians and family practitioners Improving provider
behavior on vitamin supplementation.
Improving provider behavior on vitamin
supplementation. |
Davenport ML, Uckun A, Calikoglu AS. Pediatrician patterns of
prescribing vitamin supplementation for infants: do they
contribute to rickets? Pediatrics 2004; 113(1 pt 1):179-80.
Letter. |
|
Developing an “Innovation Community” to Improve Pediatric
Practice |
Lannon |
American Academy of Pediatrics |
Develop and test effective tools for translating evidence into
practice improvement strategies Turning evidence of best
practice into usable tools for community providers |
On-going |
|
MedMARx: Improving care through analysis of pediatric medication
error data |
Cousins |
USP |
Identify
priority areas for practice improvement. |
Medication errors: experience of the United States Pharmacopeia
(USP) MEDMARX reporting system. Santell JP, Hicks RW, McMeekin
J, Cousins DD. Journal of Clinical Pharmacology 2003;
43(7):760-7.
USP drug safety review: the dangers associated with
vaccinations. Santell JP, Cousins DD, Hicks R. Drug Topics
October 20 2003; 147:HSE16.
Medication errors in the LDRP: identifying common errors through
MEDMARX reporting. Beyea SC, Kobokovich LJ, Becker SC, Hicks RW.
AWHONN Lifelines 2004; 8(2):130-140. |
|
Safety and Efficacy of Continuous Subcutaneous Blood Glucose
Monitoring Systems in the Management of Type 1 Diabetes Mellitus
in Children |
Calikoglu, Davenport |
|
Document the advantages of continuous subcutaneous glucose
monitoring in pediatric patients (and clarifying good practices
in studying devices in pediatric populations) Providing better
and more detailed data for diabetes management. |
Lagarde WH, Barrows FP, Davenport ML, Kang M, Guess HA,
Calikoglu AS. Continuous Subcutaneous Glucose Monitoring in
Pediatric Type 1 Diabetes Mellitus: A Single-Blind, Randomized
Controlled Trial. Pediatric Diabetes 2006; 7(3):159-164. |
|
A
Model Pediatric Therapeutic Drug Monitoring Service to Improve
Patient Outcomes |
Vinks,
Walson |
Cincinnati Children’s; North Carolina Children’s |
Analysis of whether standard-of-care uses of therapeutic drug
monitoring of aminoglycosides are correctly deployed for better
outcomes Teaching caregivers how to incorporate drug monitoring
into care. |
Publication forthcoming |
|
Project |
PI(s) |
Partners |
Description |
Publications/Products |
|
Efficacy, Safety, and Pharmacokinetics of Drugs in Pediatric HIV |
Walson, Vinks |
Cincinnati
Children’s
Hospital |
High-pressure liquid chromatographic method to develop
sensitive, specific, practical assay that could detect any of
the four protease inhibitors most commonly used clinically (indinavir,
ritonavir, saquinavir, and nelfinavir) in human plasma samples.
Improve therapeutic drug monitoring to give practitioners a
clearer picture of circulating levels of protease inhibitors in
children with HIV |
Touw
et al., 2005 |
|
Optimizing prescribing and treatment for otitis media. |
Christensen |
|
To
determine the impact of antibiotic prescribing at initial visit
on the probability and frequency of AOM-related return visits
among North Carolina (NC) Medicaid patients. Optimize
prescribing and treatment of otitis media in North Carolina
Medicaid population |
Ayyar-Krishnan
A and Christensen DB 2002.
|
|
Prevalence of Type II Diabetes in Childhood |
Davenport |
Bowman
Gray School of Medicine and Wake Forest Baptist Medical Center. |
Measuring fasting blood glucose in frozen serum samples obtained
in 1997 from 638 9th- and 10th-grade students to determine
undiagnosed glucose intolerance. |
|
|
Learning from Errors in Ambulatory Pediatrics |
Mohr |
American Academy of Pediatrics Pediatric Research in Office
Settings (PROS) Network. |
Develop a web-based reporting tool for errors and near misses in
pediatric ambulatory settings, identify the types of errors and
near misses that are occurring in children. Support quality
improvement initiatives and safety reporting in ambulatory
pediatric settings |
Mohr
et al. 2003a; 2003b |
|
MedMARx Medication Error Reporting System
|
Cousins |
United
States Pharmacopeial Convention, Inc. |
Evaluation of in-patient error reporting system. Improve
practice through patient safety studies using the MedMARx™
Medication Error Reporting System |
Cowley
et al. 2001; Santell et al. 2003; |
|
Pediatric Adverse Drug Event and Reaction Reporting Program –
UNC Hospitals |
Daniels |
|
Create
a reporting process to improve the process of event reporting
and patient care while maintaining confidentiality and the
protection of information. Expand benchmarking data for
inpatient and outpatient therapeutic monitoring through a
pediatric adverse drug event and reaction reporting program |
|
|
Use of
Psychotropic Drugs in Population-based Ambulatory Care
Prescribing
patterns of psychotropic drugs for adolescents.
|
Shatin |
Center
for Health Care Policy and Evaluation, United Health Care |
Helping providers understand patterns of psychotropic
prescribing.
Retrospective
analysis administrative database to address use of psychotropic
drugs to treat depression and ADHD. Avoid adverse drug events
from psychotropic drugs through use of monitoring and
surveillance data from ambulatory care |
Shatin
and Drinkard, 2002 |
|
Drug
Metabolism in Children with and without Cystic Fibrosis |
Kennedy |
|
Standardize the use of phenotyping in children with cystic
fibrosis (CF) to evaluate whether CF caused changes in drug
clearance rates |
Kennedy et al. 2004a; Kennedy et al. 2004b |
|
A
Tailored Implementation Strategy for Pediatric Therapeutic
Guidelines |
Savitz |
|
Cross-sectional, multi-level assessment of CPG typology and
tools for tailoring and adapting CPGs to different settings.
Design a tailored implementation strategy for therapeutic
guidelines |
|
|
Skeletal Effects of Oral Replacement of Vitamin D and Calcium in
Adolescents with Cystic Fibrosis. |
Ontjes |
|
Assess
the role of vitamin D and calcium in preventing osteopenia and
osteoporosis using a controlled trial with one treatment arm and
one control group, each with 30 adolescents who will receive a
calcium supplement of 500 mg. per day. Expand use of bone
density and vitamin D guidelines for care of patients with
cystic fibrosis |
Ontjes
et al., 2000. |
|
Guidelines for Assessment of Pediatric Outcomes: Innovations in
Best Practices AKA Evidence-based Tools to Assess the Pediatric
Population |
Lohr |
RTI |
Improve practitioners’ ability to assess the benefits and
potential harms of therapies using best practices for children’s
quality of life assessment |
Scientific Advisory Committee, 2002 |
|
Short
Course in Evidence-based Medicine and Pharmacovigilance for
Pediatric Practitioners |
Lohr |
|
Conduct a “Short Course” on “Using Evidence on Therapeutics to
Enhance Quality” |
Lohr
et al., 2001; Roper et al., 2002 |
|
North
Carolina Asthma Improvement Project
|
Lannon |
UNC
Children’s Primary Care Research Group and Glaxo Wellcome |
A
statewide educational effort to share knowledge about strategies
for improving care of children with asthma--a three-hour
interactive continuing medical education (CME) session and a
learning collaborative within a NC AHEC region. Improve provider
adherence to asthma guidelines in office-based practice through
coordinated educational effort |
|
|
Attention Deficit -Hyperactivity Disorder (ADHD) Project |
Lannon |
AAP,
NICHQ |
Design
and test tool kits and process improvement strategies for
practitioners to use in the diagnosis and management of
attention deficit-hyperactivity disorder (ADHD). Improve
diagnosis and treatment of ADHD through standardized “toolkit”
for practitioners |
ADHD Toolkit |
|
CERTs
Summer Institute: Using the Evidence on Therapeutics to Enhance
Quality of Care.
|
Campbell |
|
Educational activity. |
Summer
Institute Meeting |
|
Prevalence of
vitamin D-deficient rickets in minority infants. |
Davenport |
|
Survey
of NC pediatric primary care providers on attitudes toward
vitamin D supplementation during breast-feeding; case evaluation
of ethnicity of all rickets patients at two NC tertiary medical
centers; proposal for state public health policy change.
Document the prevalence of Vitamin D-deficient rickets in
minority populations and taking policy actions |
Calikoglu and Davenport 2003; Davenport et al., 2004; Kreiter et
al., 2000 |
